Publications

               

[*Correspondence]

University of Tennessee (2018 – Present)

  1. Jiang J* and Yu Y (2020) Small molecules targeting cyclooxygenase/prostanoid cascade in experimental brain ischemia: Do they translate? Medicinal Research Reviews (In Press).
  2. Li L, Sluter MN, Yu Y and Jiang J* (2020) Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy. Pharmacological Research (In Press).
  3. Yu Y and Jiang J* (2020) COX-2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures. Epilepsia Open 5:418-431.
  4. Li L, Yu Y, Hou R, Hao J and Jiang J* (2020) Inhibiting the PGE2 Receptor EP2 Mitigates Excitotoxicity and Ischemic Injury. ACS Pharmacology & Translational Science 3:635-643.
  5. Hou R, Yu Y, Nguyen DT, Sluter MN, Li L, Yang J and Jiang J* (2020) Prostaglandin receptor EP2 is a novel molecular target for high-risk neuroblastoma. bioRxiv:2020.2002.2024.963108. (Preprint)
  6. Yu Y, Li L, Nguyen DT, Mustafa SM, Moore BM, and Jiang J* (2020) Inverse agonism of cannabinoid receptor type 2 confers anti-inflammatory and neuroprotective effects following status epileptics. Molecular Neurobiology 57:2830-2845.
  7. Nagib MM, Yu Y and Jiang J* (2020) Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus. Pharmacology & Therapeutics 209:107504.
  8. Yu Y, Nguyen DT, and Jiang J* (2019) G protein-coupled receptors in acquired epilepsy: Druggability and translatability. Progress in Neurobiology 183:101682.
  9. Dawn A, Yao X, Yu Y, Jiang J* and Kumari H* (2019) Assessment of the in vitro toxicity of calixarenes and a metal-seamed calixarene: a chemical pathway for clinical application. Supramolecular Chemistry 31:425-431.
  10. Qiu J, Li Q, Bell KA, Yao X, Du Y, Zhang E, Yu JJ, Yu Y, Shi Z* and Jiang J* (2019) Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. British Journal of Pharmacology 176:1680-1699.
  11. Jiang J*, Yu Y, Kinjo E, Du Y, Nguyen H and Dingledine R (2019) Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury. Neuropharmacology 149:149-160.

University of Cincinnati (2015 – 2018)

  1. Jiang J*, Van TM, Ganesh T and Dingledine R (2018) Discovery of 2-piperidinyl phenyl benzamides and trisubstituted pyrimidines as positive allosteric modulators of the prostaglandin receptor EP2. ACS Chemical Neuroscience 9:699-707.
  2. Hartings JA, York J, Carroll CP, Hinzman JM, Mahoney E, Krueger B, Winkler MKL, Major S, Horst V, Jahnke P, Woitzik J, Kola V, Du Y, Hagen M, Jiang J and Dreier JP (2017) Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction. Brain 140:2673-2690.
  3. Kang X, Qiu J, Li Q, Bell KA, Du Y, Jung DW, Lee JY, Hao J and Jiang J* (2017) Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Scientific Reports 7:9459.
  4. Jiang J*, Qiu J, Li Q and Shi Z* (2017) Prostaglandin E2 signaling: alternative target for glioblastoma? Trends in Cancer 3:75-78.
  5. Qiu J, Shi Z* and Jiang J* (2017) Cyclooxygenase-2 in glioblastoma multiforme. Drug Discovery Today 22:148-156.
  6. Dey A, Kang X, Qiu J, Du Y and Jiang J* (2016) Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside. Trends in Pharmacological Sciences 34:413-423.
  7. Du Y, Kemper T, Qiu J and Jiang J* (2016) Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus. Expert Review of Neurotherapeutics 16:123-130.
  8. Du Y, Seibenhener ML, Yan J, Jiang J and Wooten MC (2015) aPKC phosphorylation of HDAC6 results in increased deacetylation activity. PLOS ONE 10:e0123191.
  9. Fu Y, Yang M-S, Jiang J, Ganesh T, Joe E and Dingledine R (2015) EP2 receptor signaling regulates microglia death. Molecular Pharmacology 88:161-170.
  10. Jiang J*, Yang M-S, Quan Y, Gueorguieva P, Ganesh T and Dingledine R (2015) Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. Neurobiology of Disease 76:126-135.
  11. Varvel NH*, Jiang J* and Dingledine R* (2015) Candidate drug targets for prevention or modification of epilepsy. Annual Review of Pharmacology and Toxicology 55:229-247.

Prior to 2015

  1. Ganesh T, Jiang J and Dingledine R (2014) Development of second generation EP2 antagonists with high selectivity. European Journal of Medicinal Chemistry 82:521-535.
  2. Ganesh T, Jiang J, Yang M and Dingledine R (2014) Lead optimization studies of cinnamic amide EP2 antagonists. Journal of Medicinal Chemistry 57:41734184.
  3. Rojas A, Jiang J, Ganesh T, Yang M, Lelutiu N, Gueorguieva P and Dingledine R (2014) Cyclooxygenase-2 in epilepsy. Epilepsia 55:17-25.
  4. Yan J, Seibenhener ML, Calderill-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW and Wooten MC (2013) SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PLOS ONE 8:e76016.
  5. Ganesh T*, Jiang J*, Shashidharamurthy R and Dingledine R (2013) Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS Medicinal Chemistry Letters 4:616-621.
  6. Jiang J* and Dingledine R* (2013) Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection. Trends in Pharmacological Sciences 34:413-423.
  7. Seibenhener ML, Zhao T, Du Y, Calderill-Barbosa L, Yan J, Jiang J, Wooten MW and Wooten MC (2013) Behavioral effects of SQSTM1/p62 overexpression in mice: Support for a mitochondrial role in depression and anxiety. Behavioural Brain Research 248:94-103.
  8. Quan Y, Jiang J and Dingledine R (2013) EP2 receptor signaling pathways regulate classical activation of microglia. Journal of Biological Chemistry 288:9293-9302.
  9. Jiang J*, Quan Y, Ganesh T, Pouliot WA, Dudek FE and Dingledine R (2013) Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proceedings of the National Academy of Sciences of the USA 110:3591-3596.
  10. Jiang J* and Dingledine R (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. Journal of Pharmacology and Experimental Therapeutics 344:360-367.
  11. Jiang J*, Ganesh T, Du Y, Quan Y, Serrano G, Qui M, Speigel I, Rojas A, Lelutiu N and Dingledine R* (2012) Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proceedings of the National Academy of Sciences of the USA 109:3149-3154.
  12. Jiang J, Ganesh T, Du Y, Thepchatri P, Rojas A, Lewis I, Kurtkaya S, Li L, Qui M, Serrano G, Shaw R, Sun A and Dingledine R (2010) Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proceedings of the National Academy of Sciences of the USA 107:2307-2312.
  13. Jiang J, Parameshwaran K, Seibenhener ML, Kang MG, Suppiramaniam V, Huganir RL, Diaz-Meco MT and Wooten MW (2009) AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus 19:392-406.
  14. Traffina J, Geetha T, Jiang J and Wooten MW (2008) Identification of a conserved consensus site for TRAF6/p62 substrate polyubiquitination. Biochemical and Biophysical Research Communications 371:521-524.
  15. Jiang J, Suppiramaniam V and Wooten MW (2006-2007) Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity. NeuroSignals 15:266-282.
  16. Geetha T, Jiang J and Wooten MW (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Molecular Cell 20:301-312.
  17. Jiang J, Duan S and Zhang H (2000) Cloning and expression of caiDE genes in coli BL21(DE3). Acta Microbiologica Sinica 40:586-590. (In Chinese)
  18. Jiang J and Zhang H (1998) Metabolism & production of L-carnitine. Progress in Biotechnology 18:41-45. (In Chinese)
  19. Wu Z, Jiang J and Guo J (1997) Study on pedigree seed produced techniques of cotton variety resistance to insects. Hubei Agricultural Sciences (2):13-16. (In Chinese)